Heart Failure – Page 2

Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity.

Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity. Yan G, Han Z, Kwon Y, Jousma J, Nukala SB, Prosser BL, Du X, Pinho S, Ong SB, Lee WH, Ong SG. Circ Res. 2024 Mar 1;134(5):482-501. PMID:38323474. doi: 10.1161/CIRCRESAHA.123.323683

Adult human cardiomyocyte mechanics in osteogenesis imperfecta.

Adult human cardiomyocyte mechanics in osteogenesis imperfecta Lee, BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A. Am J Physiol Heart Circ Physiol., 2023 Oct 1;325(4):H814-H821. Epub 2023 Aug 11. PMID: 37566108. doi: 10.1152/ajpheart.00391.2023.

An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3. Thompson AD, Wagner MJ, Rodriguez J, Malhotra A, Vander Roest S, Lilienthal U, Shao H, Vignesh M, Weber K, Yob JM, Prosser BL, Helms AS, Gestwicki JE, Ginsburg D, Day SM. J Am Coll Cardiol Basic Trans Science, 2023 Aug2;8(9):1198-1211. [...]

Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy.

Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy. Luciani M, Montalbano M, Troncone L, Bacchin C, Uchida K, Daniele G, Wolf BJ, Butler HM, Kiel J, Berto S, Gensemer C, Moore K, Morningstar J, Diteepeng T, Albayram O, Abisambra JF, Norris RA, Di Salvo TG, Prosser BL, Kayed […]

Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy.

Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC Jr, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z. Nat Cardiovasc Res. 2022 Sep;1(9):817-829. Epub 2022 Aug 29. PMID: 36776621. doi: 10.1038/s44161-022-00117-6.

Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms.

Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms. Vite A, Caporizzo MA, Corbin EA, Brandimarto J, McAfee Q, Livingston CE, Prosser BL, Margulies KB. Basic Res Cardiol. 2022 Aug 25;117(1):41. PMID: 36006489. doi: 10.1007/s00395-022-00952-5.

The microtubule cytoskeleton in cardiac mechanics and heart failure.

The microtubule cytoskeleton in cardiac mechanics and heart failure. Caporizzo MA, Prosser BL. Nat Rev Cardiol. 2022 Jun;19(6):364-378. Epub 2022 Apr 19. PMID: 35440741. doi: 10.1038/s41569-022-00692-y. Review.

Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure.

Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure. Phyo SA, Uchida K, Chen CY, Caporizzo MA, Bedi K, Griffin J, Margulies K, Prosser BL. Front Cell Dev Biol. 2022 Apr 1;10:837486. eCollection 2022. PMID: 35433678. doi: 10.3389/fcell.2022.837486.

Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.

Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling. Uchida K, Scarborough EA, Prosser BL. Annu Rev Physiol. 2022 Feb 10;84:257-283. doi: 10.1146/annurev-physiol-062421-040656. Epub 2021 Oct 6. PMID: 34614374. Review.

Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force.

Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. McAfee Q, Caporizzo MA, Uchida K, Bedi KC, Margulies KB, Arany Z, Prosser BL. J Clin Invest. 2024 Jan 16;134(2):e170196. PMID: 37943622 doi: 10.1172/JCI170196.

Publications Categories: Heart Failure