Microtubule dynamics control the direction of cardiomyocyte growth. Scarborough EA, Randell R, Uchida K, Stone KR, Margulies KB, Prosser BL. Science. 2026 Apr 23:eadz1970. doi: 10.1126/science.adz1970. Epub ahead of print. PMID: 42024777.
The cytoskeleton drives abnormal chromatin-lamina interactions in LMNA-deficient cardiomyocytes. Shen K, Shields K, Barka V, Karnay A, Kurzlechner L, Yang J, Wang Q, Lee BW, Suay-Corredera C, Nguyen S, Joyce E, Margulies KB, Prosser BL, Shah P, and Jain R. J Cell Bio. 2026 May 4;225(5):e202506137. doi: 10.1083/jcb.202506137. Epub 2026 Mar 27. PMID: 41891953
Active transport of tRNAs facilitates distributed protein synthesis. Petrosino J, Courelli V, Uchida K, Bond C, Cooperman B, Bogush A, Lakadamyali M, Prosser BL. bioRxiv. 2026.01.26.698744. PMID: 41659417. PMCID: PMC12874057. doi:10.64898/2026.01.26.698744.
A microtubule cage damages weakened nuclei in a genetic cardiomyopathy. Nat Cardiovasc Res. 2025 Nov;4(11): 1464–1465. doi:10.1038/s44161-025-00745-8. PMID: 41174300. Epub 25 Oct 31. Research briefing.
Microtubule forces drive nuclear damage in LMNA cardiomyopathy. Pavlov DA, Heffler J, Suay-Corredera C, Dehghany M, Shen KM, Zuela-Sopilniak N, Randell R, Uchida K, Jain R, Shenoy V, Lammerding J, Prosser B. Nat Cardiovasc Res. 2025 Nov;4(11):1501-1520. doi: 10.1038/s44161-025-00727-w. Epub 2025 Oct 10.
Water-Soluble Molecular Wires for Membrane Potential Imaging. El Khatib M, Fye MA, Uchida K, Obaid AL, Troxler T, Valente D, Salzberg BM, Prosser B, Kaverina IN, Vinogradov SA. Angew Chem Int Ed Engl. 2025 Sep 8;64(37):e202508660. doi: 10.1002/anie.202508660. Epub 2025 Jul 30. PMID: 40734524.
Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes. Erlich I, Douvdevany G, Haddad R, Prosser BL, Kehat I. bioRxiv. 2025 May 6. doi: https://doi.org/10.1101/2025.05.05.652192.
ROR2 drives right ventricular heart failure via disruption of proteostasis. Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards […]
Chronic Activation of Tubulin Tyrosination Improves Heart Function. Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herrera-Rivero M, Siebels B, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo M, Lindner D, Prosser BL, Carrier L. Circ Res. 2024 Sep 16. doi: 10.1161/CIRCRESAHA.124.324387. […]
Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, […]