Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kücük E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, Kremer H, Prosser BL, Epstein DJ. Dev Cell. 2021 May 17;56(10):1526-1540.e7. Epub 2021 […]
Microtubules orchestrate local translation to enable cardiac growth. Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL. Nat Commun. 2021 Mar 11;12(1):1547. PMID: 33707436. doi: 10.1038/s41467-021-21685-4.
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser […]
Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. Margulies KB, Prosser BL. Circ Heart Fail. 2021 Jan;14(1):e008006. Epub 2021 Jan 12. PMID: 33430601. doi: 10.1161/CIRCHEARTFAILURE.120.008006.
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL. Circ Res. 2020 Jul 3;127(2):e14-e27. Epub 2020 Apr 10. PMID: 32272864. doi: 10.1161/CIRCRESAHA.119.315947.
Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Circulation. 2020 Mar 17;141(11):902-915. Epub 2020 Jan 16. PMID: 31941365. doi: 10.1161/CIRCULATIONAHA.119.043930.
A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL. Circ Res. 2020 Jan 31;126(3):e10-e26. Epub 2019 Dec 11. PMID: 31822208. doi: 10.1161/CIRCRESAHA.119.315582.
Cardiac microtubules in health and heart disease. Caporizzo MA, Chen CY, Prosser BL. Exp Biol Med. 2019 Nov;244(15):1255-1272. Epub 2019 Aug 9. PMID: 31398994. doi: 10.1177/1535370219868960. Review.
Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE. Dev Cell. 2019 Jun 17;49(6):920-935.e5. Epub 2019 May 16. PMID: […]
Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Caporizzo MA, Chen CY, Salomon AK, Margulies KB, Prosser BL. Biophys J. 2018 Nov 6;115(9):1796-1807. Epub 2018 Sep 28. PMID: 30322798.doi: 10.1016/j.bpj.2018.09.019.